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This drug is a first new class therapeutic agents called Cannabinoid-1 Receptor blocker that treats obesity and related conditions. This drug blocks receptors found in the brain and in peripheral organs that is necessary in glucose and lipid metabolism that includes adipose tissue, the GI tract and the liver. It switches off the brain circuits that make the people hungry. This receptor decrease the over activity of the endocannabinoid system. It is important in regulating body weight and in controlling energy balance. This drug is a complement to diet and exercise that aids obesity and overweight patients who suffer from Type 2 diabetes and has abnormal levels of fat in the blood. It is said to prevent the risk of cardiovascular disease. It is also for patients with a waistline of 88-102 cm.
It was Europe who first started to use this drug together with diet and exercise with patients having a BMI of greater than 30. In UK, it was available as of July 2006 and in 2008 it was readily available in 56 countries. It was October 2008, where European Medicines Agency concluded that benefits of Acomplia no longer outweighed its risks and it is recommended to be withdrawed in the market. The risk where related to serious psychiatric problems and suicide that comes along with taking this drug. Later on, Sanofi Aventis released a press statement indicating that the drug had been suspended for further review.
First you have to talk to your physician before taking this drug and all the other drugs you are taking while on Acomplia medication. This drug is available in two forms: 10 and 20 mg. It must be taken on empty stomach for faster absorption and it is suggested to avoid eating breakfast for 1 hour after taking the medication. If you forgot to take a certain dose, take the next scheduled dose and never take an extra tablet for the dose that you missed. It can cause harmful effects on the body if you overdose.
After this drug was introduced in the market, there have been independent studies suggested that the side effects are stronger as what is stated by the manufacturer studies. There have been reports that says taking this drug causes frequent depression and it promotes neurodegenerative diseases of the brain like Multiple sclerosis, Hungtington’s disease, alzheimer’s disease and amyotrophic lateral sclerosis. It is suggested that people with underlying neurological condition should not take this drug.